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Baldur's Gate II: Throne of Bhaal Hints
How do I kill Melissan?
1 of 4: Well, don't get all excited yet. This is the first of four times you're going to have to kill her.
2 of 4: She keeps summoning all sorts of nasty demons, beholders, and slayer shadows.
3 of 4: Ignore them -- she summons them every few rounds and you can't keep up without using most of your efforts, plus they disappear when she does.
4 of 4: Hit her. Repeatedly. Very hard. In this round, you shouldn't need much in the way of special moves, as she leaves at Badly Injured status to go collect more essence.