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Bioshock Hints
Spider Splicer Tips
1 of 7: This one is much harder to kill than the others you've encountered. A single frag grenade won't take most of her life away like it did with them.
2 of 7: Before you let her see you, go back the way you came and find the health station that's in a side area, past some stairs and on the left. She'll try to use it when her health gets low, so either hack it or destroy it if you haven't already.
3 of 7: Go get her attention, then get her to follow you most of the way to the health station you just hacked.
4 of 7: Near the bottom of the stairs that lead up to the health station's side area is a hole in the floor that you can drop into.
5 of 7: Crouch down and walk underneath the grated part of the floor that has a board on it.
6 of 7: Hopefully, the spider splicer won't run off, but will walk around above you to where you can shoot her with the pistol, machine gun, and/or shotgun.
7 of 7: NOTE: It would help a bit if you used Telekinesis to remove the board from the grated flooring before starting the combat.