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Bioshock Hints
Splicer Combat Tips
1 of 4: If you have some prox mines to spare, you could lay one or two of them in front of the door before it's cut open. (Don't put them too close to the door, or they'll be detonated prematurely.)
2 of 4: Or you could start tossing frag grenades or chemical thrower napalm through as soon as it's cut open.
3 of 4: Or you could start tossing Enrage plasmids when the splicers run into your room, then retreat through the doorway you entered the room through earlier.
4 of 4: Any of those ways should damage the splicers enough that you can easily finish them off.