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Bioshock 2 Hints
Defeat the Big Sisters.
1 of 6: Right after you use the door controls, run over to the SW corner of the area and stand next to the wall vent.
2 of 6: Get out the drill and let Natural Camouflage turn you invisible while you wait for the big sisters to arrive.
3 of 6: The first one should be instantly killed by your prox mine trap. If not, you may want to quickrestore and add another prox mine or two to the trap, or reclaim and reposition all of the mines. (Or just quickrestore and try again without changing anything, since the first big sister's exact drop-down point is somewhat random.)
4 of 6: Wait until the second big sister destroys all of your bots and turrets, then drill-dash her.
5 of 6: If you spliced in all of the good drill tonics, you should be able to kill the big sister fairly easily with drilling and drill dashes. (Don't forget to use a first aid kit if your health ever gets dangerously low.)
6 of 6: NOTE: If you have too much trouble killing the second big sister, you might want to restore your quicksave and lay another prox mine trap somewhere so you can lead her through it. Just don't let it blow you up!