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Bioshock 2 Hints
How can I use splicers to weaken a big daddy?
1 of 3: If splicers are already attacking a big daddy, stay back and let them damage him as much as they can before he kills them.
2 of 3: If a nearby splicer isn't attacking a big daddy, maneuver him into accidentally hitting the big daddy while he's shooting at you.
3 of 3: Or if you have the Hypnotize plasmid, hit the splicer with it. He'll then attack the big daddy if he's closer to it than to you or any other splicers.