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Bioshock 2 Hints
Pick up the Little Sister.
1 of 3: Loot the big daddy for items, then go up to the little sister.
2 of 3: Press the key that the game prompts you to (F on the PC) to pick her up. (If F doesn't work, try the SPACEBAR.)
3 of 3: NOTE: You'll get this goal again after each ADAM extraction is complete. All you have to do is pick up the little sister again like before.