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Duke Nukem 3D Hints
How do I beat the boss?
1 of 12: Make sure to get rid of all of the Protozoid Slimers in this room before taking on the boss.
2 of 12: Before opening the door, throw ALL of your Pipebombs in front of the entrance.
3 of 12: Do the same with some Tripbombs, but don't get too close or the door will open.
4 of 12: Now, put on run mode and open up that door!
5 of 12: Detonate everything, and the boss should sustain a serious amount of damage.
6 of 12: Wearing down the boss without getting yourself killed is the toughest part.
7 of 12: Circle around him, staying away from the walls.
8 of 12: Fire with either the RPG or Devastator.
9 of 12: Move quickly, because those missiles shoot fast.
10 of 12: Stay away too, so you don't get stomped on.
11 of 12: If you stay alive and hit him enough, he should fall!
12 of 12: Well, looks like Duke kept his promise to the Overlord. :)