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Duke Nukem 3D Hints
Octabrain
This guy is the enemy that really ticks me off. If you hear the annoying scream that they make, beware! They look like large, floating squids, and they take tons of hit. In addition to firing psychic blasts at you, they can bite you to shreds at close distances. However, the psychic blasts can be dodged (move quick!), and if you keep far away, you'll obviously be safe from their teeth. Personally, I think the best way to deal with them is to get at a far-away distance, and blast them unto death with an RPG or Devastator. You can use other weapons, but it will take many, many rounds of ammo to kill them.