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Duke Nukem 3D Hints
Sentry Drone
The best way to know when these guys are coming is the sound that they make -- they sound suspiciously like the Imps from DOOM. In any case, when they see you, they charge at you and explode when they get close enough. Run backwards and shoot the Drones while they're homing in on you. They seem to take a couple of hits, so one shot won't do it.