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Fallout: New Vegas Hints
Get into the investigator's room at the Ultra-Luxe.
1 of 4: Look in the side area to the right of Mortimer's desk for a door that leads to the hotel rooms area.
2 of 4: Go up the stairs and open the first door on the right, then quicksave. When you enter the room, two White Glove thugs will run in and attack you.
3 of 4: Hopefully, you managed to keep a few holdout weapons when you entered the casino that you can use on them now. Try running straight into the bathroom and V.A.T.S.-attacking them one at a time as they follow you.
4 of 4: NOTE: If you need a better weapon, you can try pickpocketing Heck Gunderson's shotgun or the nearby bartender's dress cane.