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Fallout: New Vegas Hints
Is there some way to get a key?
1 of 5: Go outside and talk to Marco, who's sitting near the entrance.
2 of 5: If you ask him about Saint James, he'll mention that he likes the hooker named Sweetie.
3 of 5: Go back inside and find Sweetie in an upstairs room, then talk to her about getting into Saint James' room.
4 of 5: If you offer to pay for the key and have 250 caps, you'll be able to buy it.
5 of 5: If you don't have the caps or would rather keep them, pickpocket the key from Sweetie.