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Fallout 3 Game Add-Ons (DLC) Hints
Desmond's Eyeglasses
1 of 3: These unique glasses have the following properties: damage resistance +1, Explosives +5, Small Guns +5.
2 of 3: Desmond the ghoul, who lives in the Calvert Mansion, is wearing them.
3 of 3: You'll have to kill him to get them, and it's best to wait until after this add-on's main quest series is over to do that.