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Fallout 3 Hints
Inventory Tip
1 of 4: Before you go anywhere, put all of your excess items into a nearby locker.
2 of 4: You'll want to be carrying as few non-weightless items as possible, ideally just your one best weapon and your best armor.
3 of 4: The reason for this is that you'll soon be going to a place that you can't ever get back into once you leave it, and there's a lot of heavy loot there to carry away. (And you can't take a follower there with you to help you do the carrying.)
4 of 4: So dump all the non-weightless items that you can part with, and remember where you put them so you can come back and get them after finishing the next quest.