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Fallout 3 Hints
Which flavor should I choose?
1 of 3: The berry ones boost Intelligence by 5, the grape ones boost Charisma by 5, and the orange ones boost Perception by 5.
2 of 3: You'll probably want to choose grape, since regular mentats boost both Intelligence and Perception by 5, making the berry and orange mentats redundant, and mostly inferior.
3 of 3: I say "mostly" inferior since fruit-flavored mentats aren't addictive like regular mentats are. If you frequently use mentats to boost your Intelligence or Perception, the berry or orange mentats may actually be useful to you since you can use them frequently without becoming addicted. (Though that won't matter much if you've finished the "The Power of the Atom" misc. quest and bought the "my first laboratory" item for your home.)