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Fallout 3 Hints
Boot up the mainframe.
1 of 4: Go back up to the big upstairs room, then find the mainframe door in its west wall.
2 of 4: Open the door and go through it, then look around for an interactive item.
3 of 4: Straight ahead from the door is a red keyboard with a switch to the right of it.
4 of 4: That's the mainframe power switch, so activate it to finish this objective.