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The Orange Box: Half-Life 2: Episode Two Hints
Poison Headcrab Tip
1 of 3: Let it see you, then back up a ways so that Alyx is between you and it.
2 of 3: She should notice it and shoot it to death before it can leap at either one of you.
3 of 3: Or you can use the gravity gun to grab the large rock that's near the top of the stairs, then throw it at the headcrab to kill it instantly.