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Bioshock Hints
Specific ADAM-spending Recommendations
1 of 9: After you harvest or rescue the first little sister in the Medical Pavilion, buy the Enrage plasmid from the nearby Gatherer's Garden machine. It's useful enough to spend ADAM on even before you start buying new slots.
2 of 9: The garden machine in Neptune's Bounty has two plasmid slots to sell, and the one in Arcadia has one plasmid slot and two each of the three tonic slots.
3 of 9: All of those items together will cost a total of 840 ADAM, so be sure to spend ADAM on nothing else until you manage to get them all.
4 of 9: In order to get 840 ADAM, you'll need to rescue or harvest at least six little sisters.
5 of 9: There are two in the medical pavilion and three in Neptune's Bounty, so if you've gotten all of those, you'll just need to get one in Arcadia.
6 of 9: The garden machine in the Farmer's Market has the same slot selection as the one in Arcadia, which is enough to max out all your slots. However, you won't have enough ADAM to buy them all until you've gotten to Fort Frolic.
7 of 9: After you have all six slots for your plasmids and the three tonic categories, your next priority is the max health and EVE increases.
8 of 9: Just about every garden machine sells one of each, so after you save up a bunch of ADAM, go back to all the previous garden machines and buy theirs.
9 of 9: As for Electro Bolt, Incinerate, and Winter Blast, you can make do with the free versions of Electro Bolt and Incinerate until late in the game, when you're able to upgrade to version 3 of all of those. If you buy any of the intermediate versions, you may not ever be able to get enough ADAM to buy everything mentioned above. (Remember that the garden machines all the way through the Proving Grounds area will have health and EVE upgrades. Also, there are a couple of useful garden-only tonics you might want to get.)