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Bioshock 2 Hints
What rewards can I get for rescuing little sisters?
1 of 5: Nothing at first. After you rescue four little sisters, you'll get a special reward that includes the Proud Parent tonic and 80 ADAM.
2 of 5: After the next four rescues, your reward will include the Demanding Father tonic and 120 ADAM.
3 of 5: If you also rescue the last four, you won't get any special tonics, but you will get 250 ADAM.
4 of 5: The first reward tonic helps you get more ADAM from extractions, and the second one makes extractions go a little faster. Even if you use the first tonic all the time after you get it, you'll still end up getting a bit less ADAM than if you harvested all of the little sisters.
5 of 5: That means there's little tangible motivation to ever rescue any little sisters other than getting the "good" game-ending cut-scenes. If you don't care about that, you can harvest as many as you wish.