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Fallout 3 Game Add-Ons (DLC) Hints
Post-Quest Notes
1 of 5: Loot the dead protectrons in the brain's room, then go through the west door.
2 of 5: Move straight ahead from there to find the reward vault. You can open its door if you got the key from Desmond, and the door will already be open if you killed Desmond first and then the brain.
3 of 5: Loot the vault of stuff, including more mesmetron power cells and the unique Microwave Emitter gun. (And no, it's not the reason there have been so many mesmetron power cells around here -- it uses microfusion cells, the same as energy rifles do.)
4 of 5: You can explore the rooms to the north of that for a bit more stuff. When you're ready to leave, use the ladder in the reward vault.
5 of 5: If you originally sided with Desmond, all of the tribals at the cathedral will still be hostile to you. You might want to go and clear out the place so you can pick refined punga fruit in peace.